Manipulatable Intracoronary Wire Team Members: Allison McArton Angwei Law Grant Smith Padraic Casserly Client: Dr. Vik Chhokar, Dept. of Medicine Advisor: Prof. John Webster, Dept. of Biomedical EngineeringOutline Guidewires and You Guidewire Design What We Want… Design Requirements Solution Ideas Evaluation of Ideas Future WorkGuidewires and You Inserted distally in the groin or arm Maneuvered to position in coronary arteries Inserted past blocked region Delivery mechanism for stents Typically 350 µm in diameter and 150-350 cm longGuidewire Design Stainless steel or Nitinol core Platinum outer coil wire at distal end Soft polymer coating and tip Problems with previous steerable designsWhat We Want… A novel coronary guidewire is to be developed such that torqueability along the wire's entire length is maintained and the wire's tip conformation can be changed in vivo via external operationPDS Design Requirements Biocompatible/ percutaneous Steerable and torqueable Maximum diameter of 350 µm Product Characteristics Durable in tortuous environments Easily manipulated MiscellaneousDesign Idea #1: Sheath Wire set as J-shape Wire straightens when sheath pushed over tip Could also be implemented vice versa Already used on a larger scale https://lifeassistshop.life-assist.com/CatalogImages/FullSize/01_at2780a.jpgDesign Idea #2: Pneumatic Wire pre-stressed in a curved state Hollow core leading to distal cavity Pressurization of internal air straightens wireDesign Idea #3: Memory Metal Nickel Titanium/Nitinol Shortens when heated to transformation temp Crystal structure Can be heated with electricityDesign Matrix Ease of Manufacturing 35 30 20 25 Performance 35 25 30 30 Ease of Use 20 16 20 20 Monetary Cost 10 9 8 7Future Work Determine most suitable method to bind Nitinol wire to stainless steel wire Obtain Nitinol wire with desired phase transformation temperature Construct a scaled-up prototype Carry out testingAcknowledgements Dr. Vik Chhokar Prof. John Webster Prof. Wendy
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