Week 6 Progress Report Project: Injection Catheter for stem cells Team: Adam Goon – Team Leader Joel Webb– Communications Andrew Bertram – BWIG Michael Conrardy – BSAC Week: October 3- October 15 Client: Tim Hacker Dept. of Medicine UW School of Medicine and Public Health Phone: 263-1539 email: [email protected] Advisor: Prof. John Webster 2148 Engineering Centers Building 1550 Engineering Drive Madison, WI 53706 Problem Statement Different methods have been tried to deliver stem cells to damaged cardiac tissue caused by a heart attack or other disease. These methods include injecting cells into the general circulatory system, injecting directly into the coronary arteries or open heart surgery to inject cells directly into the heart muscle. These methods have been ineffective for delivering a large number of cells to the damaged tissue or are invasive. A minimally invasive method of delivering stem cells directly into and around the damaged tissue is needed. Currently, injection catheters are inserted in the femoral artery and advanced to the left ventricle (LV). Once in the LV, the catheter can be steered to the desired locations on the LV walls and a needle can be extended out from the tip of the catheter to penetrate the heart muscle and inject stem cells. This is a very time consuming process to make the multiple injections of stem cells necessary to heal the damaged tissue. In addition, with current tip designs lack of anchoring the needle in the muscle wall during the injections leads to fewer cells injected into the muscle and it is also time consuming to calibrate the depth of needle penetrations as needle depth is altered by the curve the of the catheter as it is bent into the necessary positions to reach damaged tissue. Therefore, a new catheter which can speed up the process of stem cell injection will be of critical importance to successful delivery of stem cells to the heart. A method is needed to improve precision of needle penetration and lessen the time to complete the procedure. This could be done by having multiple injections into the heart without adjusting thecatheter and employing a corkscrew needle or other designs to securely anchor the needle in the tissue and control the depth of penetration. Last Week’s Goals • Create the powerpoint for the mid-semester presentations • Practice for mid-semester presentation • Decide which design to move forward with and start developing ideas to construct it • Develop drawings of designs (possibly solidworks) Accomplishments • Developed powerpoint presentation • Determined three designs to compare and decide which to continue with • Create solidworks of design and other drawings • Practiced for presentation This Week’s Goals • Give midsemester presentation • Discuss with client the designs we created and the one we would like to pursue • Contact catheters companies for guidance • Develop plan to start building catheter Difficulties • Team members were gone for conference part of the week making it difficult to meet Team Effort Team Member Accomplishments Time (Hrs) Adam Goon Individual research, team meeting 5 Joel Webb Individual research, team meeting 3.5 Andrew Bertram Individual research, team meeting 3.5 Mike Conrardy Individual research, client meeting 5 Current Progress:Expenses to Date: • No expenses to report at this time. September October November December Task 4 11 18 25 2 9 16 23 30 6 13 20 27 4 11 WORK Brainstorming Research Designing Prototype Selecting Prototype Obtaining Materials Building Prototype Testing Prototype Modifications DELIVERABLES PDS Mid-Sem. Presentation Final Report Final Presentation Weekly Reports Notebooks MEETINGS Team Meetings Client Meetings Advisor Meetings BSAC Meetings OTHER Web Page Special
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