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UW-Madison BME 300 - Mouse Restraint Device

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Mouse Restraint Device Week 12-13: November 20-December 4, 2009 Team: Eamon Bernardoni – Co-Leader Brooke Sampone – Co-Leader Samantha Paulsen – Communicator Vanessa Grosskopf – BWIG Jim Mott – BSAC Client: Justin Jeffery UW Comprehensive Cancer Center UW School of Medicine and Public Health Phone: (414) 690-6030 Email: [email protected] Advisor: Walter F. Block Associate Professor, Biomedical Engineering Phone: (608) 265-9686, Email: [email protected] Problem Statement: The Small Animals Imaging Lab located in the Wisconsin Institutes for Medical Research is in need of a solid, adjustable device that will restrain mice during Positron Emission Tomography and Computerized Tomography (PET/CT) scans. These scans are used to pinpoint cancerous growths within the animal prior to treatment. The device must restrain the animal’s extremities to prevent movement and must include a quantitative analysis device to replicate the animal's exact anatomical position. The device should improve efficiency for animal restraint compared to the current cardboard restraint device. Previous Week’s Goals: The team plans on meeting with John Floberg on Friday to fabricate the pegs for attaching the device to the carbon fiber bed and the pegs for restraining the mouse. We also plan on working with the registration software to start testing the realignment of the mice during multiple scans. The overall goal is to fabricate multiple beds after meeting in the lab Friday. Work on the final poster will be finalized. We also need to obtain concrete testing data to validate our device. Activities: The team worked with John Floberg to determine the Hounsfield unit of our device and the pegs. We sanded the rods in the lab on Friday and then glued them to the carbon fiber on Tuesday. The Wednesday before Thanksgiving the first set of tests were completed. Jim registered all of the data from the scans. On Monday another set of scans were completed. Work was completed on the poster and it was printed on Wednesday. On Thursday, the team completed the fabrication of five additional beds and included the client’s suggestions in these devices. Summary of Accomplishments: The team tested the initial prototype and Jim analyzed all of the scans. With input from the client, the team fabricated five additional devices so the client now has six mouse restraint devices. The poster was completed and printed for Friday’s presentation. Next Week’s Goals: After the poster presentation tomorrow, the only remaining tasks are to write the final paper, complete self and peer evaluations, update the website, and deliver our design to the client.Difficulties: There are no difficulties at this time. Project Schedule: Tasks Sept Oct Nov Dec 4 11 18 25 2 9 16 23 30 6 13 20 27 4 11 Research X X X X Brainstorming X X X X X X PDS X X X X Prototype Design X X X Prototype Fabrication X X X X Testing X X X X X Meeting with Client X X X X X X X Team Meeting X X X X X X X X X X X X X Presentation X X Written Reports X Peer/Self Evaluations X Expenses: 12”x12”x1/8” ABS Sheet Beige $7.76 5’ ABS Rod 1/4" Diameter, Beige $2.80 10’ Natural Halar Miniature Cord 0.0625” OD $3.66 5’ ABS Tube 1/2" OD X 1/4" ID Black $7.11 Total w/o shipping


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UW-Madison BME 300 - Mouse Restraint Device

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