Mouse Restraint Device Week 11: November 13-November 19, 2009 Team: Eamon Bernardoni – Co-Leader Brooke Sampone – Co-Leader Samantha Paulsen – Communicator Vanessa Grosskopf – BWIG Jim Mott – BSAC Client: Justin Jeffery UW Comprehensive Cancer Center UW School of Medicine and Public Health Phone: (414) 690-6030 Email: [email protected] Advisor: Walter F. Block Associate Professor, Biomedical Engineering Phone: (608) 265-9686, Email: [email protected] Problem Statement: The Small Animals Imaging Lab located in the Wisconsin Institutes for Medical Research is in need of a solid, adjustable device that will restrain mice during Positron Emission Tomography and Computerized Tomography (PET/CT) scans. These scans are used to pinpoint cancerous growths within the animal prior to treatment. The device must restrain the animal’s extremities to prevent movement and must include a quantitative analysis device to replicate the animal's exact anatomical position. The device should improve efficiency for animal restraint compared to the current cardboard restraint device. Previous Week’s Goals: After the team meeting on Friday the team plans on determining the next steps. One of the main goals for next week is to continue fabricating our device. The team plans on experimenting with peg material, elastics, and adhesives to see how well our current peg design will work. Once the pegs are made preliminary scan testing can be done to get practice with software. Holes need to be drilled into the peg board and attachment pegs need to be fitted. Activities: The team learned some important aspects of imaging including more about attenuation, what the Houndsfield unit is, and what information the software readouts will give us. The team began fabricating some pegs for the board and realized that it was necessary to do most of the work in the lab with an actual mouse. The team met to mill off several columns of holes on the first prototype to make the device smaller. Work on the poster also began. Summary of Accomplishments: The team learned the importance of the Houndsfield unit in imaging and what that means for our project. We also discussed testing the registration process and what results will prove our device is work according to the client’s wishes. The team also worked on fabricating the pegs and altered the first peg board. Work on the poster began. Next Week’s Goals: The team plans on meeting with John Floberg on Friday to fabricate the pegs for attaching the device to the carbon fiber bed and the pegs for restraining the mouse. We also plan on workingwith the registration software to start testing the realignment of the mice during multiple scans. The overall goal is to fabricate multiple beds after meeting in the lab Friday. Work on the final poster will be finalized. We also need to obtain concrete testing data to validate our device. Difficulties: The current material will suffice in our design but it is not ideal. The team is having trouble finding an appropriate material that will attenuate the images the least yet be structurally sound and ridged. Project Schedule: Tasks Sept Oct Nov Dec 4 11 18 25 2 9 16 23 30 6 13 20 27 4 11 Research X X X X Brainstorming X X X X X X PDS X X X X Prototype Design X X X Prototype Fabrication X X Testing X X X Meeting with Client X X X X X Team Meeting X X X X X X X X X X X X Presentation X Written Reports X Peer/Self Evaluations X Expenses: 12”x12”x1/8” ABS Sheet Beige $7.76 5’ ABS Rod 1/4" Diameter, Beige $2.80 10’ Natural Halar Miniature Cord 0.0625” OD $3.66 5’ ABS Tube 1/2" OD X 1/4" ID Black $7.11 Total w/o shipping
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