10.23.13 kin 272 class notes- Specific defenses:o Lymphocytes B cells T cellso Targeted antigens Antigenic determinants- Antigen specific- Systematic – covers entire system (head to toe)- Memory – remember previous antigens – make carbon copy, future referenceo Innate immunity – genetically determined Linked to chromosomes/DNA Ability to replicate from genes & hand them downo Acquired immunity – not present at birth Only get this immunity when exposed to the specific antigen In certain communities where you aren’t exposed, you are at a dif risk for acquiring them Need vaccinations for travellingo Active immunity Appears after exposure to antigen Immune consequenceo Passive immunity Transfer of antibodies from one source to another There is some question to how good this might be Mom placenta, baby Nursing – passive immunities to baby? Really?o Acquired is combo of active & passive sort of- Body exposed to antigeno 1st exposureo has specific glycocalyxo this antigen is engulfed by one of monocytes – big pacmano pacman (macrophage) – eats antigenso package = antigen presenting cello shows it to something else for analyzationo T cell analyzation process T cells- Matured in thymus- Helper T cellso Don’t fight anything (lymphocytes)o Responsible for analyzing sugar coatingo Look at antigen presenting cello Make decision as to who should get involved to remove foreign invadero How to classify antigens… talk about latero Call in… Cytotoxic T Cell (phagocyte) One main lymphocyte that can physically remove foreign invaders (killing lymphocyte) Crazy army guys that don’t know when to stopo Memory T cells Nucleus programmed to remember antigen on foreign invaderso Suppressor T Cells Suppress cytotoxic t cells- Helper T cell cytotoxic T cell to kill antigen memory T cell (to rememberthe antigen- Memory T cellso Stay in the system as long as you are presented with the antigeno Weeks years (depends how many times you are exposed- suppressor T cellso eliminate cytotoxic cells- cell mediated immunity (decided by helper T cell) may not be right routeo involves all T cellso more complex instead it will use a B Cell to get involved- B cell o Form of a lymphocyteo Differentiates into memory B cell and _____ plasma Cell Protein sequence on outside of antigen Clone makes memory cello Plasma cell Memorized coating Mass form tiny proteins called antibodies Secretes antibodies Made from the nucleus of a plasma cell Plasma cell came from clone Clone came from helper t talking to ito Antibodies Flags/markers Stick to foreign invader It is killed by WBCs, cytotoxic t cells, etc- Job of the B cello Not to do any fighting…o Only 2 kindso B cellso Cloneo Memory cello Plasma cell- T Cells o Helper t cello Cytotoxic t cello Memory t cello Suppressor t cell- B cells o Clone cellso Plasma cells antibodieso Memory cells- Only cytotoxic t cells actually do killing- If a foreign invader isn’t labeled with antibody, it won’t be removed, no one knows they are there- Memory t cell and memory cellso Can stay in system for a while (months-years)- Chicken pox
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