9.16.13 Kin 272 class notes- Monocyteo Largest of white blood cell familyo 2-8% of circulating WBC populationo known as tissue macrophage eat largest of foreign invaderso only in circulation for 24 hourso live for a day typicallyo summon fibroblasts (form scar tissue)- lymphocyteo 20-30% of circulating populationo immune responseo cancers linked to lymphocyteo T-cells Thymus dependent cells Located under breast bone Finish maturation hereo Remove foreign cellso Cell immunityo B-cells Bone marrow derived cell Stay in bone marrow to finish maturation Antibody mediated defense (flags/markers)- Very very specific Virus covered in antibodies is eaten!- The antibody is the flag saying that it’s a bad cell Chicken pox – once you get the virus, it is flagged by antibodies and eateno NK cell Natural killer cell Self cells that are abnormal Glycocalyx is yours – your cell- Sometimes protein is denatured and messed up- Cancer cell- Plateleto Megakaryocyte that started as hemocytoblast Explodes to form plateletso Part of clotting process- thickens ito Circulate for 9-12 days then consumed by phagocyteso Spleen holds 1/3 of body’s platelets Rupture of spleen is very bad – releases platelets- Cardiovascular o Heart 11 ounces beats over 100,000 times per day pushes blood through 60,000 miles of vessels underneath the sternum, 2/3 to left of center, 1/3 to the right of center pointed end called the apex- is inferior- points slightly forward- location can be determined from ECG- knowing location can tell you if heart has moved due to being unhealthy, too big, overtrained, etc outside most component: pericardial sac- double layered- loose fitting fibrous membrane- inbetween two layers is pericardial fluid- inside most = serous layer/visceral pericardium, attached to heart- outside most layer = fibrous layer/parietal pericardium, lungs, chest, diaphragm are attached- fluid filled to decrease friction, when it beats, it preventsfriction outermost layer of heart is the epicardium (muscle) there is adipose surrounding the heart- find it where there are coronary arteries and coronary veinso give the heart its own blood supplyo affected by high amounts of cholesterolo left coronary, right coronaryo left side gets moreo coronary bypass: clot in blood vessel there is a blockage preventing blood flow bypass is a replacement artery greater saphenous vein- can be used to bypass, is easy to get
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