10.16.13 part c kin 272 class notes- Lymphatic tissues o Mucosa associated lymphatic tissue (MALT) Digestive systemo Bundles of connective tissue that are dominated by lymphocytes- Lymphocyteo WBCo Nucleus nearly as large as cell membraneo Confused often with a basophilo 3 dif. kinds T cells- thymus derived cells- initially formed in bone marrow- omatopoeisis- halfway mature, leave bone marrow and go into circulation- go to thymus (under sternum)- matured there B cells- Bone marrow derived cells- Don’t leave bone marrow until they mature- Form there NK cell- Natural killer cell- Fewer percentage than the other cells- Responsible for looking for self cells that don’t act as selfcells- Glycocalix – protein/glycogen component has changed, don’t function as self cells- Pre cancerous killer- Kill non self cells- Do a good job catching cancer cells before they spreado In digestive system (MALT) Mucosa associated because it is in mucosa like tissue Any tissue with epithelia like mucosa membrane Epithelial cells that produce mucus (goblet cells – release mucus)o Mucosa epithelial cells that covered in mucus Protect from acido Buried in epithelial cells are chunks of…o Aggregated lymphoid nodules Nodes/trunks of lymphatic tissue Peyers patches- Small and large intestine In the respiratory system as well- Covered in mucus- Protect from particles/subparticles in the air from damaging lining of respiratory systemo Tonsils Part of digestive/respiratory system Lymphatic tissues Large nodules- Found in the walls of the pharynx- Pharynx – tube like component that sits at back of throat, food/air goes into- 5 tonsilso need to know names & locations when we get there in lab right next to oral cavity, opening in skin skin – keeps out foreign invaders invaders can get into the oral cavity- one of the largest opening- indirect control- put things into our mouth that we don’t realizeo foreign invaderso bacteria o tonsils layer themselves around throat region bombarded with bad stuff (food containing foreign invaders/bacteria)- stuff you inhale finger nail chewers, pen cap chewers…more likely to get sick/have swollen tonsils as soon as tonsils become overwhelmed… become swollen- SWOLLEN- Frequently sometimes- Swollen when not being overrun sometimes- Have them removed – over reactive to something- Lymphatic organso Lymph node – covered by thick connective tissueo Kidney bean shaped – similar to kidneyo Attached to lymph node are lymphatic vessels One way valves on insideo Afferent lymphatic vessels Lymph travels toward the nodeo Efferent lymphatic vessels Lymph leaves the nodeo Large coating around outside – thick connectiveo Divided into segmentso Similar feature to themo Outside contains lymphatic follicles Germinal center on inside of follicle- On inside of germinal center is sinus (surrounds germinal center)o In the center of the lymph node is the medulla Contains cords and sinuses Cords – dense material Sinuses- spaces between dense materialo Lymph travels through (medullary/lymphatic) sinuses Moved with fibrous hairs In the sinuses:- Macrophages (phagocytes)o Responsible for initiating immune response, cleaning of lympho Contain little fibers to keep lymph moving along- Moves from cortex to center medulla- When it reaches medulla – most of foreign particles have been removed Germinal center- Contain lymphocytes- More specific than macrophages when it comes to consuming bacteria… Follicles- Contains Lymphocytes- Initiate cell mediated immunity- Antibody mediated immunity- Highly specific types of immunity- Only related to lymphocytes- Related to bacterias, viruses, parasites, anything that gets into lymph that needs more specific killing- Regions of lymph nodeso Highly collected in areas of where lymph goes into the trunko Distributed in area to protect the major internal organs before lymph reaches those organso Ex. Armpits, shoulders, neck, groin, hip areao Threat to organs in trunko Spleen is inferior to stomach (left side) It has same identification features of lymph node Houses bacteria of body Rupturing the spleen – allows mass quantities of bacteria/viruses into the
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