9.13.13 Kin 272 class notes- Started talking about the process of forming a red blood cell- Hemocytoblast beginso Nucleus gets smaller and smaller until it is ejected- Continuing from Wednesday:o 3 tubeso 1 is 45 % normal hematocrito 1 is 65% hematocrito 1 is 35% hematocrit less oxygen carrying abilities- What does it mean to blood dope?o Increase red blood cell content o Increase plasma content- White blood cell differential o Counting/determining percentage of each of the white blood cells in circulation- Neutrophilo Multilobed nucleuso 50-70% of circulating populationo granulocyteso highly mobileo 1st responders of “EMS system”o release chemicals to attract otherso phagocytes (eat bacteria if necessary)o contain peptides, amino acids called defensins released when they need to kill other bacteriao life span of 10 hourso eat something and dieo More neutrophils – could mean you have an infectiono Too few – means you aren’t making them?- Eosinophilo Stains darker!o Attracts acidso Kidney-bean shaped nucleuso Only make up 2-4% of circulating populationo Phagocyteso Known to attack bacteriao Old worn out organelles, other waste products on insideo Attack things covered in antibodieso Undergo exocytosis of toxic compoundso Increase during allergic reactionso High number of eosinophils means you have a lot of toxic products in your blood orrr…allergic reaction- Basophilo Largest concentration of granuleso S-shaped nucleuso 1%o diapedesis white cell squeezes through layers of the blood vessel to get to tissues red cells never do this basophils do this all of the time most of them are in your tissues which is why they aren’t often in circulationo basophils travel to bruises (damaged tissues)o go to muscles after a workout for tissue repairo release granules/chemicals histamine granules- strong, potent vasodilator- makes blood flow better heparin granules- clot prevention agent- i.e. keeps clots from happening- dilate, more flow- helps with inflammation- basophils initiate this^ so you can begin repairo acute inflammation – intended to repair somethingo chronic inflammation – body is worn down, inappropriately
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