UW-Madison NUTRSCI 132 - Phytonutrients and Carcinogenesis (4 pages)

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Phytonutrients and Carcinogenesis



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Phytonutrients and Carcinogenesis

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Lecture number:
35
Pages:
4
Type:
Lecture Note
School:
University of Wisconsin, Madison
Course:
Nutrsci 132 - Nutrition Today
Edition:
1
Documents in this Packet

Unformatted text preview:

NUTR SCI Lecture 35 Outline of Last Lecture I Breastfeeding and Nutrition a Mom b Infant II Complementary foods transition a Hot topics Outline of Current Lecture I Phytonutrients a Definition II Carcinogenesis a Carcinogens b 3 stage model III Phytonutrients as anti carcinogens Current Lecture I Phytonutrients a Non nutrients found in plants i Don t develop deficiencies without them ii Help in cancer prevention iii Association between high F V intake and decreased cancer 1 F V high in nutrient density 2 Low in energy density 3 Low in fat and saturated fat 4 Anti oxidant a Oxidative damage to DNA b Vitamin C and E c Beta carotene i High supplemental doses do not have the same effect in decreasing cancer as diet rich in F V These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 1 F V have many more things besides Betacarotene Phytonutrients 2 10 000 chemicals in a tomato II Carcinogenesis a Def The process by which cancer develops b Carcinogens i Def chemicals that damage DNA and cause cancer ii Working with carcinogens in job esp before better safety regulations show clusters of particular cancers caused by exposure on the job 1 Vinyl chloride iii Food carcinogens 1 Introduced 2 Graph a General trend slow increase b Lung cancer in women increased when smoking became popular c Stomach cancer decreased Food supply safer than it used to be i Spoiled moldy food carcinogenic ii Ex Nitrates 1 Less exposure now 2 Ex Cured meats beer iii Ex Mold aflatoxin 1 Lower rates of liver cancer here than in Africa 3 Naturally Occuring a Sassafras Tea contains carcinogens c 3 stage model of carcinogenesis i Normal cell 1 Initiation a Something damages DNA mutation b Ex Carcinogen oxidative damage radiation ii Initiated Cell 1 Occurs 1 million times day a Not all mutations lead to cancer iii Promotion 1 More DNA damage 2 Multiple instances of damage iv Cancer cell 1 Abnormal 2 Single



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