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UW-Madison NUTRSCI 132 - Lipids Continued

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NUTR SCI 132 Lecture 16Outline of Last Lecture I. Lipids a. Reviewb. Transporti. HDLc. Food Sourcesd. Coronary Heart Diseasei. Pathologyii. EtiologyOutline of Current Lecture I. Blood Lipids and RiskII. Diet and Blood LipidsCurrent LectureI. Blood lipids and riska. At risk if…i. LDL > 130 mg/dLii. HDL < 35 mg/dLiii. Total Cholesterol > 160 mg/dLII. Diet and blood lipidsa. Dietary Cholesteroli. Indirect Effect1. Raw Materials >>enzyme(Metabolic Pathway)>> Cholesterola. Moderate vs. Zero Intake of Cholesterol makes no difference, but Large Intake will increase it ii. Saturated Fat1. Greatest single impact on raising Blood Cholesterol2. Sources: Animal fats, tropical fats3. Increases LDL, Total Cholesterol4. Some people have bigger responsea. Varying genetic dispositions to risk of Heart Attackiii. Polyunsaturates1. Omega-6 (most vegetable oils)a. Lower LDL and HDLThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.i. Good outweighs the negative, but still not best option2. Omega-3 (soy, canola, flax)a. Decreases blood clottingiv. Monounsaturated Fats (olive, canola)1. Lower LDL, don’t effect HDLa. Decrease the bad without harming the good!v. Trans-fatty Acid1. Raise LDLvi. Moderate Alcohol1. Raise HDL2. 3-9 drinks/weeka. 1-2 drinks/day - Mb. 1 drink/day – Fvii. Soluble Fiber-rich foods1. Decrease bile reabsorptiona. Increases Cholesterol ExcretionIII. Recommendationsa. <10% of kcals as saturated fatb. < 300 mg/day cholesterol (dietary – don’t confuse with blood lipid levels!)IV. Cancer and Lipida. Animal Studiesi. High fat diet >>> Increase in Cancer1. (Also increase overall kcal)2. Increase Omeg-6 also increase cancer…ii. Epidemiology1. Nurses Health Studya. No correlation between breast cancer and fat intakeb. ‘Low fat’ quintile really more of a ‘Medium Fat’i. Perhaps true low fat will offer protectionV. Compare DietUS Mediterranean AsianHeart Attack High Low LowFat 34% 35% 15-20%Type High Sat Fat High Monounsaturates (Olive Oi)Omega-3, Omega-6, poly, monoEnergy Complex


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