MMG301 1st Edition Lecture 35Outline of Last Lecture I. Person-person microbial diseasesOutline of Current Lecture II. Direct contact diseasesIII.Current Lecture-Staphylococcus: -S. aureus: normal flora of humans and certain animals skin and upper respiratory tract, but some types are pathogenic; produce a variety of virulence factors-Can cause these diseases:-acne, boils (skin abscess)-foodborne illness (gastrointestinal tract; food poisoning)-impetigo (outer skin infection)-blood (bacteremia, septicemia)-meningitis-wound infections-otidis media (inner ear)-endocarditis (heart), others-some types are pyogenic (cause formation of pus)-some form an abscess (enclosed formation of pus, usually from infection or an object that gets embedded in the skin)-Gonorrhea: Neisseria gonorrhoeaeThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-Gram-negative, non-motile, aerobic, diplococcus-Infect mucous membranes of genitourinary tract, eye, rectum, throat-Syphilis: Treponema pallidum; a spirochete bacterium-Entry through breaks in the epithelium; disease can progress in three stages, but this can vary1. Forms a chancre at initial infection site which later disappears (primary syphilis)2. Cells can spread to other tissues causing characteristic skin rash (secondary; disseminated) 3. A latent stage, not infectious, that can last years; lesions eventually form on skin, bone, nervous system (blindness, insanity) (tertiary)-Chlamydia: Chlamydia trachomatis – an obligate intracellular parasite (can only replicate inside host cellls-Most prevalent sexually transmitted disease in the US-Life cycle results in destruction of host cell: Stages in life cycle:1. The extracellular elementary body and enters host cell by endocytosis2. It differentiates to the metabolically active reticulate bodies, which multiply3. Reticulate bodies differentiate into more elementary bodies and exit
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