MMG301 1st Edition Lecture 24Outline of Last Lecture I. Bacterial geneticsOutline of Current Lecture II. Regulation of transcription by repressionIII. Regulation of transcription by inductionCurrent Lecture-regulation of transcription by repression-example: arginine-add arginine to medium of growing cells, genes for arginine synthesis shut down-arginine binds to free repressor protein-arginine-repressor protein complex can then bind to operator-arginine operon: conserve energy and resources by shutting off transcription of genes that aren’t needed-regulation of transcription by induction-example: lac operon-add lactose to medium of growing cells, genes for lactose utilization turn on-transcriptional regulation: -inducer binds to operator-bound repressor protein-repressor protein released from operator site-opposite strategy from arginine-population-dependent control of regulons by chemicals that are excreted by cells.-example: quorum sensingThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-quorum sensing is a way to sample the environment to measure population density-cells constantly release small molecules into the environment = “autoinducers”-different autoinducers are produced by different bacteria-allows cells to specifically sense others in their surroundings even if other bacterial types are nearby-cells release autoinducers-nearby cells take up autoinducer-inside those cells, autoinducer binds to activator protein and causes changes in regulation of several
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