UGA ADSC 2010 - Estrus Synchronization and AI
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ADSC 2010 Lecture 28Outline of Last Lecture I. Reproduction: Post-Partum Estrus A. CattleB. EweC. SowD. MareII. Management of the Reproductive Tract III. Estrus in the FemaleIV. Estrus DetectionOutline of Current Lecture I. Estrus SynchronizationA. BenefitsB. DisadvantagesC. Methodsa. Cowsb. Ewesc. Sowsd. MaresII. Artificial Insemination A. Benefits Current Lecture: I. Estrus SynchronizationA. Benefits1. Decreased time and labor involved in:- Heat detection – necessary for shorter time period- Breeding – concentrate into a 2-5 day period- Parturition 2. Increased conception rate- Ovulation time would be known and “Time AI” could be used3. Increase use of AI- Allows greater use of superior genetics4. More efficient use of facilities- Breeding, parturition, weaning, and marketing could be better planned5. Important in ET (Embryo Transfer)B. Disadvantages1. Success rate can be low2. Requires more intensive management3. Amy be cost prohibitive- GnRH: cystorelin, factrel, and Fertagyl = $6.50/dose- PGF2α: lutalyse, estrumate, and prostamate = $2.50/dose- Progesterone: CIDR = $8/dose- Progesterone: melengestrol acetate (MGA) C. Methodsa. Cows1. Progesterone or progesterone-type compounds- Administration: oral, injectable, and vaginal insert)- Inhibits follicular development and ovulation, allows CL to regress at cow’s normal time and prevents new CL from forming- After removal, follicle develops and ovulation occurs 2-4 days later- Can be used in conjunction with prostaglandin- CIDR (intravaginal progesterone releasing device)o Day O: insert CIDRo Day 6: IM injection of prostaglandin(lutalyse, etc)o Day 7: Remove Inserto Day 8-12: Estrus detection and AI (12 hr. post estrus)o Introduce clean-up bull2. Prostaglandin (PGF2α)- Administration: IM injection- Causes CL to regress any time after day five of cycle - Approximately 1/3 of cow herd will not respond to single injection- Can be used in conjunction with progesterone - Lutalyse, estrumate, prostamateo Day 0: Inject IMo Day 0-7: Heat detect and AI (12hr. post-estrus)o Day 14: Inject IM to non-responderso Day 14-21: Heat detect and AI (12hr. post-estrus) or “Timed AI” (76-80 hr. post-injection)3. Gonadotropin-Releasing Hormone (GnRH)- Administration: injection- Causes release of LH followed by ovulation and CL development- Also initiates development of a new dominant follicle 2-3 days later- Used in combination with PGF2α- Cystorelin, factrel or Fertagyl and lutalyse, estrumate or prostamateo Day 0: Inject GnRH IMo Day 7: Inject PGF2α IMo Day 6-12: Heat detect and AI (12hr. post-estrus)ORo Day 6-10: Heat detect and AI (12hr. post-estrus)o Day 10: Inject GnRH IM and “Timed AI” (72 hr)4. Combination of Progesterone, GnRH, PGF2α- Administration: Progesterone: Oral, GnRH & PGF2α: Injections- MGA, cystorelin, etc, and lutalyse, etc.o Day 1-14: Feed MGA (.5 mg/head/day)o Day 15: Remove MGA from feedo Day 26: Inject GnRH IMo Day 33: Inject PGF2α IMo Day 33-40: heat detect/AIo Day 41: Introduce clean-up bullb. Ewes- Not used to a great degree- If used, mainly vaginal progesterone sponges and PGF2α IM injectionc. Sows- PGF2α not effective until after day 14 of cattle (not very useful)- Some progesterone compounds usedo Oral for 18 days, remove and estrus will occur 4-6 days laterd. Mares- No real programs/not enough research doneII. Artificial Insemination A. Benefits 1. Allows use of genetically superior sires 2. Helps control diseases, particularly venereal disease3. Eliminates excess males on the farm- Safety issued with handling- Reduces costs: feed, facilities, etc.4. Allows for accurate record keeping**AI is an essential component of an estrus synchronization

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UGA ADSC 2010 - Estrus Synchronization and AI

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