BME402 BME Design Date 3 1 07 Title Microencapsulation of tissues and cells for treatment of hormone related diseases microencapsulation Project 4 Client Dr Craig Atwood Faculty Advisor Professor William Murphy Team Members Eric Lee Team Leader Yik Nong Wong Jacqueline Communicator Miguel Benson Communicator John Harrison BSAC Albert Kwansa BWIG Dates 2 24 07 3 1 07 Week 6 Project Design Statement To investigate the effects of thickness UV radiation exposure and RGD adhesion molecules on the viability and testosterone production of human prostate cancer cells embedded within polyethylene glycol diacrylate hydrogel The overall goal of this project is to design an encapsulation system that offers efficient immunoprotection and effective diffusion of oxygen nutrients hormones and metabolic wastes Conceptually the stated encapsulation system along with embedded human prostate cancer cells will enable the restoration of un regulated testosterone levels commonly observed in elders and retard the symptoms of aging Restatement of Previous Team Goals 1 Team meeting to compile questions for Professor Tim Stiles of Medical physics department on using ultrasound as a measuring method for hydrogel thickness 2 Contact client for training and an update on the cell line 3 Mock presentation of K 12 activity Summary of Team Accomplishments 1 Compile question and answers for the meeting with Professor Tim Stiles of the Medical physics department a Bulk modulus of hydrogel b Density differences between water and hydrogel c Flat parallel surface for ultrasound measurement Current Individual Goals Eric Lee Practice K 12 outreach presentation Contact Amy to obtain HPLC data on our PEGdA product Work on Mid semester presentation slides Carry out hydrogel swelling ratio experiments Jacqueline Wong Practice K 12 outreach presentation Get trained to maintain cell lines on Monday Contact Professor Wally Block to obtain information on BME402 BME Design Date 3 1 07 possible contrasting agents for using ultrasound method to measure hydrogel thickness Work on Mid semester presentation slides Miguel Benson Practice K 12 outreach presentation Contact Madison East high school to confirm Wednesday presentation date Work on Mid semester presentation slides John Harrison Practice K 12 outreach presentation Get trained to maintain cell liens on Monday Work on Mid semester presentation slides Carry out hydrogel swelling ratio experiments Albert Kwansa Practice K 12 outreach presentation Obtain a Team picture and work on the project website Find more information on the UV light bulbs to be used in the client s lab Work on Mid semester presentation slides Carry out hydrogel swelling ratio experiments Summary of Team Goals 1 Get HPLC data of our PEGdA product 2 Carry out hydrogel swelling ratio 3 Get trained and an update on the cell line 4 Obtain new bulb for the UV light 5 K 12 outreach activity
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