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UW-Madison BME 200 - Bioreactor for Tissue Engineering

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Bioreactor for Tissue Engineering, Team Bioreactor Week 8 – March 15 to March 21, 2007 Team Members: Karen Chen – Team leader Richard Bamberg – Communications Rachel Mosher – BSAC Dustin Gardner – BWIG Client: Dr. Susan Thibeault Dept. of Otolaryngology, UW Medical School Phone: 608/263-6751, Email: [email protected] Advisor: Brenda Ogle Assistant Professor/ Dept. of Biomedical Engineering Phone: 608/265-8267, Email: [email protected] Problem Statement The aim of this project is to redesign and reproduce a pre-existing Bioreactor that is specific to the culturing of human vocal fold fibroblasts. The existing design models the vibration of a single vocal fold under tensile stress and provokes the elongation of fibroblasts and the subsequent formation of an extra-cellular matrix, characteristic of vocal fold fibroblasts. Our goal is to improve upon this model by simulating contact between two vibrating vocal folds and potentially finding a better substitute for Tecoflex, because its porosity is non-uniform and the pore size is too large. The bioreactor will be made from a T-flask with elastic vibrators immersed in a buffer, which will function as vocal folds. This device needs to be easily replaced with disposable parts, along with 2 pairs of artificial vocal folds and a capacity to generate (computer controlled) vibrations at a frequency (0-400Hz). Restatement of Team Goals This week we plan to settle and problems about the voice coil actuator. We might not take the speaker components apart. Instead, we will deal with an actuator. We must have the parts of the prototype fixed, and start the ordering of the components. The team shall decide on the details of the prototype. We will meet with the client on Friday to discuss more about this. Individual Goals Dustin Update website, research on base& vibration bar Karen Send out the progress report, research on rods/pipettes & connector Rachel Research on actuator& output board/motion controller& linear amp& feedback sensorRichard Send out contacting emails between the client and the team, research on T-flask& boots Summary of Accomplishment z The team met on Thursday (Mar. 15) to discuss talk about whether to break apart a speaker or to get an actuator. After knowing the difficulties of dealing with speaker parts, we decided to go with the actuator. z The met during class time on Friday (Mar. 16) and researched on individual components and found prices of some bioreactor parts. We also estimated the size of the actuator base, and found the unit price of the pipettes. z We met with the client on Friday (Mar. 16) and decided that we will use the client’s grant as the money source (need to check up on this). The client wants to use the magnetic actuator. She also said that we should probably use the peel-back T75 flask. z On Wednesday (Mar. 21), Rachel spoke with an engineer at H2W about the voice coil actuator. He stated it would be hard to have a total required travel of 0-20 mm and maintain a frequency of 400 Hz, he then provided Rachel with quotes of two different actuators: 1) The smaller ($711) actuator can provide a higher frequency, but only has a stroke of 3.8 mm. 2) The larger ($797) actuator probably cannot provide a frequency of 400 Hz, but has a stroke of 25.4 mm. There are also many actuators available that are on the "middle ground". Statement of Team Goals The goal of this week is to get most of the components ordered, and to continue the ordering process into next week. We also need to make sure that we understand how individual parts fit together in the original design. We should start planning on how to put the components together when they arrive, since our design is somewhat different from the design found in the literature search. Difficulties We are currently facing the problem on how to come up with a realistic and doable design of the bioreactor as a project. The construction of the bioreactor by the previous builders seemed to be very complicated. Activities Dustin 03.19.2007 Research on base& vibration bar 2.00h 2.00h 03.21.2007 Researching on pipette & connector 1.00h 03.21.2007 Doing rough sketches 0.25h Karen 03.21.2007 Progress report write up 1.00h 2.25h Rachel 03.16.2007 Researching closed loop system and components 0.50h 4.00h03.18.2007 Talking with father about actuator and bioreactor 1.00h 03.18.2007 Coming up with and sketching design ideas 0.50h 03.21.2007 Communicating with H2W about actuator, communicating with Susan about parts, looking up equations, researching function generators 2.00h Richard N/A Researching components 3.00h 3.00h 03.15.2007 Regular group meeting 1.00h 03.16.2007 Discussion with advisor in class 0.50h Team 03.16.2007 Meeting with client 0.50h 2.00h Project Timeline Jan February March April May Tasks 26 2 9 16 23 2 9 16 23 30 6 13 20 27 4 9 11Project research Brainstorming PDS Prototype design Prototype building Actual device design Ordering Expected shipping Device manufacturing Testing Re-designing Re-testing Meeting with client Group meeting Presentation Progress report Website Expenses Currently there is no

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