BOLOGY 107 Lecture 9 Outline of Last Lecture I Organelles a Mitochondria b Chloroplast c Endosymbiosis theory d Peroxisome e Cytoskeleton Outline of Current Lecture II Organelles a Bulk Transport b Plasma Membrane Current Lecture Organelles 1 Bulk Transport a Exocytosis i Secretion of materials 1 Vesicles from endomembrane system fuses with plasma membrane releasing the contents outside the cell 2 Plasma Membrane a Segregate domains i Keep outside on the outside and the inside in b Semi permeable membrane i Allows certain molecules to pass blocks others c Basis for organization i Micro fibrils anchor to membrane d Information relay via signals e Contains phospholipid bilayer as main structure scattering of cholesterol proteins and associated carbohydrates f Visualizing structure i Fluid mosaic model 1 Mosaic o lipids and macromolecules 2 Random distribution 3 Free motility of molecules These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 4 Some subdomains like lipid rafts are not random or freely mobile g Membrane fluidity and proteins i Fluidity 1 Dynamic constant lateral movement rarely flipping movement 2 Antigens or antibody targets show fluidity a When rat and human cells with different antibodies fused antibodies of both cells were found in almost even distribution around the cell rather than split in half 3 Affected by temperature if the phospholipids are saturated or unsaturated cholesterol and integral proteins h Proteins i Integral 1 Directly imbedded in membrane transmembrane 2 Some only go through half the membrane not through both sides 3 Made in the endomembrane system ii Peripheral 1 Loosely attached 2 Associated with phospholipids or integral proteins iii Function 1 Transport enzymatic activity signal transduction cell recognition intercellular joining cytoskeletal attachment 2 Target for viruses a Infect cells by specific binding to cell surface proteins b Immunological pharmacological or genetic intervention prevents this
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