Conserved sited 9115 9961 1 There are 96 variable sites out fo 29883 total sites There are 29727 conserved sites out of 29727 total sites 2 Variable sites 53 9961 There are fewer variable sited because these are known as evolution flexible This means that these are the genes that can change and cause changes in characteristics and traits which contribute to evolution The conserved sites are the evolutionary stable traits These traits allow us to keep the basic function of life that we need to survive they are locked into our genetic code because they are essentials 3 The position of my mutation is 21551 29883 and it is variable 53 9961 when translated This mutation is a substitution 4 5 The strain that is most unlike the others in the Omicron strain This has the furthest distinctive genetic code form another strain listed on this tree On the other side we see the close relation of the strain found in New York and the strain found in Iowa When compared to the rest strains in California Arizona and Texas we see that Iowa and New York are geographically closer to each other They share a region climate and conditions closer than any other location mentioned in the tree This shows that the corona virus adapted to be more suitable for the conditions of the North Eastern part of the United States 6 I believe constructing trees of isolates on a global scale can be an extremely useful tool for investigators to trace transmissions These trees can be a good tool for identifying patterns amongst the disease being tracked such as race impacted area impacted region impacted countries where different strains derived from etc These trees allow investigators to analyze genetic sequences of pathogens to compared to see the relations and trends This in turn helps us understand how it spreads which will help us know how to contain or control the spread of said disease by informing the public Lab Activity 4 Protein Phylogenetic Tree I do see 4 fairly distinct groupings on the phylogenetic tree that I 7 produced When you see large groupings like this it means that they are related via whatever is the determining factor of the tree In this case the tree is built from the relations of kinase So when we see these relations it means that the kinases of the individuals in the groupings are closely related in terms of their kinase We see the flow of evolution through this tree From what I see there were four main pathways that the kinase enzyme took from the relative base of the evolutionary process wherever and whenever it started 8 Kinase is an enzyme catalyst that inhibits the transfer of a phosphate group from adenosine triphosphate to a specific molecule Lab Activity 5 Genomic Epidemiology of COVID 19 9 Hover over an isolate with both nucleotide and amino acid mutations What is the amino acid mutation write out the name of the amino acids affected You may need to use a codon table online 1 Isolate Source 2 Mutation 10 No not all nucleotide mutations lead to amino acid mutations This is because different combinations of amino acids can still code for the same thing For example there are four 4 different combinations of nucleotides al code for the amino acid pro Cytosine Cytosine Uracil Cytosine Cytosine Cytosine Cytosine Cytosine Adine and Cytosine Cytosine Guanine 11 No in order to have an amino acid mutation a nucleic acid mutation is absolutely necessary Nucleic acids are what code for the amino acid They are the blue prints per se The body follows these blueprints to a T So therefor in order to have an amino acid mutation there would need to be a difference in the nucleic acids that are the indicators for that specific amino acid
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