Slide 1Slide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Highly Parallel Fabrication of Nanopatterned Surfaces with Nanoscale Orthogonal Biofunctionalization Imprint LithographyH. E. Gaubert and W. Frey, Nanotechnology 18 (2007) 135101Devang Parekh3/21/07EE235Devang Parekh EE235OverviewMotivationFabricationResultsConclusionDevang Parekh EE235MotivationNanopatterned surfacesBiosensorsTissue engineering scaffoldsBio-MemsSelf-assembly techniquesPattern parametersPattern defectsLack of dual functionalityE-beam and Ion-beamSerialCost prohibitiveDevang Parekh EE235FabricationQuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.Step and Flash (SFIL) Quartz templateBottom Antireflective Coating (BARC) planarization layerBARC spin-coated 45nmLow-viscosity resistPhotoresist fills templateHarden PR with UV exposureStepM. Stewart, et. al, J. Microlith., Microfab., Microsyst. 4, 011002 (2005)Devang Parekh EE235FabricationO2 etch residual photoresist2nd O2 etch to transfer pattern to BARCEvaporate 3nm of CrEvaporate 17nm of AuLift-offDevang Parekh EE235FabricationO2 plasma remove residual organicsHexadecanethiol (HDT)Polyethylene Glycol-silane (PEG-silane)FibronectinHuman umbilical vein endothelial cells (HUVECs)Devang Parekh EE235ResultsAFM physico-chemical mappingForce is random for untreatedHDT is hydrophobicPEG is less hydrophilic than clean wafernm-resolution of physico-chemical differencesDevang Parekh EE235ResultsDevang Parekh EE235ResultsDevang Parekh EE235ConclusionSoft litho->micro NOBIL->nanoOrthogonal functionalization shownSimple and cheap fabricationPossible extension to glass or polymer
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