1 Deletion of APC tumor suppressor gene on chromosome 5 or p53 chromosome 17 2 A mutant proto oncogene often RAS Only 5 10 of all cancers are related to an inherited gene mutation Questions Tobacco Smoke Cancer How APC s relation to Colon cancer Heredity Lecture 11 Inherited Mutations Facts Inherited Cancer Recessive vs Dominant Genes Smoking and Lung Cancer Types Non small cell carcinoma 85 detected early treated surgically Small Cell Carcinoma 15 Lung carcinoid tumor 5 Mutations of p53 and K ras in Lung Cancer Affects G in DNA Colorectal Cancers Screen for it 2 leading cause of cancer related deaths in the U S Easy enough to cure because it s a slow progression Polyps develop in the epithelium of the colon Polyps are benign growths Polyps get bigger Acute Lymphoblastic Leukemia Treatment of childhood cancers and long term problems Nests of malignant cells appear in polyps Screening Recommendations 2 A mutant proto oncogene often RAS Fecal occult blood Colonoscopy 1 Deletion of APC Childhood Cancers Leukemia Secondary Cancers Heart Damage Lung Damage Infertility Chronic hepatitis Alterations in growth and development Stem Cell Lineage and Leukemia T cells part of adaptive immune system Leukemia and Lymphoma Bone Marrow chemotherapy Lymphomas Hodgkin s Disease See owl eyes under a microscope Non Hodgkin s Lymphoma Rapidly fatal if not caught when localized Bone marrow transplants after chemotherapy Alcohol and Cancer Alcohol stimulates cell division Oral Cavity larynx pharynx and esophagus Breast Cancer Liver Cancer Vaccine for it HPV can screen for and catch early Common increase in cervical cancer E6 and E7 causes it
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