Lecture 11 The transforming principle Fred Grif ths 1920 was working on Pneumococus which causes pneumonia Takes the smooth glistening virulent bacteria and injects it into the mouse and it dies Takes the rough dull non virulent bacteria and injects it into the mouse and it lives He kills the smooth glistening virulent bacteria via heat and injects it into the mouse and it lives He takes the dead virulent bacteria and the rough dull non virulent bacteria and injects it into the mouse and it dies He does an autopsy and sees live smooth glistening virulent bacteri 1943 Avery McCanty and McLeod They continue to purify the substance until they could tell it was DNA 2 deoxy ribose Base Terphosphate Structure of DNA Bacterial Viruses Structure of DNA Double helix Studied by Al Hershey and Martha Chase 35 s labeled virus protein 32 p labelled virus DNA C is always matched with G and T is always matched with A
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