Recitation 6 Pedigrees Autosomal recessive non sex chromosome Transmits to males and females equally Unaffected parents give rise to a quarter of affected progeny If both parents are affect all of the progeny will be affected Examples cystic fybrosis and sicle cell anemia Autosomal dominant Non sex chromosome Transmits to males and females equally Usually one affected individual in each generation Unaffected parents never give rise to affected progeny Sex linked recessive Can be x or y linked Transmits to males and females different Normal males never transmit the trait Much more prevalent in males If the female is affected all of the progeny will be affected Reasons that the real world pedigree would not look the same Variable expressivity different gradients to the amount the trait is expressed Incomplete penetrance can be a carrier but not affected even with the allele
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