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MIT 7 012 - IMMUNOLOGY 2

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7.012 IMMUNOLOGY 2C.Match the following statements with the appropriate cell type(s).Choose from:• All body cells • B cells • Helper T cells• Neurons • Macrophages • Killer (cytotoxic) T cells1) destroy infected body cells2) specifically bind soluble antigen3) present peptides on class II MHC4) present peptides on class I MHC5) stimulate B cells6) undergo somatic recombinationD.The varicella zoster virus (VZV) is the infectious agent that results in chickenpox, acommon childhood illness that causes itchy red spots on the skin. Contracting VZV as achild is relatively benign, but can present serious health issues when contracted as anadult.i) How does a VZV infected cell signal the immune system? How are the infected cellsspecifically eliminated from the body.ii) Over the course of a lifetime, the average person is exposed to VZV many times,yet usually only displays symptoms once. What is the immune system mechanism thatresults in lifetime resistance?As of September 1999 any child entering kindergarten must have had chickenpox orreceived a new vaccine against VZV.iii) Present an argument in support of this vaccination campaign.iv) Present an argument opposed to this vaccination campaign.MIT Biology Department7.012: Introductory Biology - Fall 2004Instructors: Professor Eric Lander, Professor Robert A. Weinberg, Dr. Claudette


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MIT 7 012 - IMMUNOLOGY 2

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