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All of the female offspring have normal colored eyes half of the males have normal colored eyes and half of the males have white eyes In Morgan s lab a white eyed y was born They set up a cross between the white eyed y and a normal eyed y All of the offspring were normal eyed They set up a cross between a normal eyed female and a white eyed male Lecture 9 Sex linkage in ies F F F F Human Pedigrees Is this autosomal recessive autosomal dominant or sex linked recessive Sex linked recessive Normal males never transmit the trait The phenotype is much more prevalent in males Only carrier moms pass on the mutant allele 50 of sons show the trait If you have an affected female all of her sons will be colorblind Autosomal dominance Equal prevalence in males and females Transmits to each generation Affected parent transmits to half of its kids Unaffected parents never transmit Sometimes incomplete penetrance maybe 80 of mutants are affected Autosomal recessive Unaffected parents yet a quarter of the offspring are affected Studied by Archibald Garrod in 1908 This trait occurs often times in the mating of rst cousins The pee has homogentisic acid HGA This is because they babies were unable to breakdown the acid When Garrod fed the babies a lot of protein or phenyl dine tyrosine and homogentisic acid there was no change


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MIT 7 012 - Lecture 9

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