Recitation 11 Viruses Made up of nucleic acid DNA or RNA and protein They are very small Have a tiny genome Written as Capsids vs envelope Capsids wont fuse to the host cell because they do not have glyco proteins like enveloped proteins Nucleic acids makes up DNA or RNA Core proteins make up to neucleo capsid Outside of the virus is a protein coat called a capsid Repeating structure of one protein over and over again What happens when viruses infect cells Lytic cycle The virus shoots its DNA into the cell It hijack the cells machinery It produces more viral DNA DNA replication It preforms translation in order to make the protein to package the DNA in the form of capsids or envelopes Lyses fattens up the cell unit it bursts the cell in order to release all of the newly made viruses Class 1 dsDNA virus hijacks host s machinery Class 2 ssDNA virus hijacks host s machinery Class 3 dsRNA virus needs RNA dependent RNA polymerase which is not inside of the host cell Class 4 ssRNA virus same polarity as mRNA needs RNA dependent RNA polymerase Class 5 ssRNA virus complementary to the mRNA needs RNA dependent DNA polymerase If it goes through the DNA intermediate it needs RNA dependent DNA polymerase reverse transcriptase DNA DNA dependent DNA polymerase RNA DNA dependent RNA polymerase History of Cancer Chicken with a tumor The tumor was then removed ground up and put in another chicken that then got cancer The ALV avian lukemia virus with SRC an oncogene produces RSV SRC causes growth which explains the tumor because it is unregulated proliferation ALV virus integrates into the genome and by chance it integrated next to SRC SRC codes for a proteins called kinase which is a tyrosine kinase Kinases add phosphates
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