BIO 0150 1nd Edition Lecture 31 Outline of Last Lecture I Harvesting Energy Outline of Current Lecture II Harvesting Energy continued Current Lecture Glycolysis pyruvate oxidize CAC to yield four ATP and 12 electron carriers o When glucose is fully oxidized many reduced electron carriers are produced with a small amount of ATP produced The majority of ATP production from glucose occurs by oxidative phosphorylation o Electron transport ATP synthesis NADH and FADH2 donate electrons to the electron transport chain on the inner mitochondrial membrane o Upon donation of electrons NADH and FADH2 are re oxidized to NAD and FAD The electron transport chain is an ordered series of electron carriers o Electrons are carried by prosthetic groups and inorganic cofactors in the ETC o Electrons can enter the ETC via two doors Complex 1 Complex 2 o From complex 1 and complex 2 the electrons are transferred to ubiquinone coenzyme Q o The final electron acceptor in the chain is oxygen o Electron transfers are an exergonic process o The energy released from electron transfers is used to actively transport protons from the matrix to the inter membrane space Proton transport generates an electrochemical gradient Potential energy is stored in this electrochemical gradient Protons move through a proton channel in the inner mitochondrial membrane o F subunit of ATP synthase o Energy released by gradient dissipation is used to spin rotate the rotor shaf o Shaf spinning changes conformation of F1 catalytic subunit of ATP synthase to allow ATP synthesis ATP yields NADH versus FADH2 These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Electron transport and ATP synthesis can be uncoupled o Uncoupling of electron transport and ATP synthase occurs in brown fat and allows non shivering thermogenics
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