BIOSC 150 1nd Edition Lecture 10 Outline of Last Lecture I. Subcellular StructuresOutline of Current Lecture 1. Subcellular structures continuedA. Intermediate filaments and microtubules2. Disease Current LectureThree types of filamentous proteins comprising the cytoskeleton:1. Microfilaments(actin) – small diameter, polymer made of actin monomers2. Intermediate Filaments – intermediate diameter, polymer made of various proteins depending on the cell type3. Microtubules – large diameter, polymer made of the proteins alpha and beta tubulin-Use crystallography to see three-dimensional structure of a protein-Use scanning electron microscopy to look at the surface of tissue and large objectsIntermediate filaments- provide the cell with tensile strength1. Long chains, more elongated than actin2. Huge diverse array3. Rope-like structure4. Good to resist tense forces5. Can distinguish different cell types-IF cell type can help to show the origin of the cell type therefore determining a treatment plan for cancer, in particular Metastatic cancerDemosomes- intermediate filaments that are critical for cell-cell interactionsHemidesomes- intermediate filaments critical for cell-substratum interactions-Intermediate filaments help to structure the cellThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-Nuclear lamins are IFs that give the nucleus shape and anchor chromosomes-IF subunits are anti-parallel heterotetramers (four different subunits)-IFs have no directionality because both ends are identical-Microtubules are composed of alpha and beta tubulin heterodimers-Microtubules form a radical network in the cell-Microtubules organize at the microtubule organizing center (MTOC)-MTOC in animal cells is the centrosome-Microtubules are asymmetric and have polarity-Microtubules are important for directional transport of cargo within cells-Motors walk along microtubules using energy in the form of ATP-Kinesin and dynein control coloration in
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