BIOSC 150 1nd Edition Lecture 5Outline of Last Lecture I. PtroteinsOutline of Current Lecture II. HemoglobinA. Hemoglobin – factor in disease III. Patient Study CasesIV. Sickle Cell DiseaseCurrent Lecture-When identifying sickle cell disease, send out blood samples to be viewed under a microscope-Red blood cells are packed with hemoglobin to carry oxygen-Sickle cells block blood flow leading to pain and swellinga) Sickle cells are sticky and stifb) The stifness and stickiness leads to the blockage-Oxygen concentration is high in the lungs and low in peripheral tissues-Sickle red blood cells are filled with fibers-Normal blood cells are not filled with fibers-Red blood cells sickle on slide when oxygen concentration is lowered-One may perform a test to determine which biomolecule makes up the sickle cella) The cell could be composed of lipids, carbs, proteins, or nucleic acidb) A possible test would include using specific dyes to identify the biomoleculec) Another test would include adding particular reagents to the cell*The fibers are composed of abnormal hemoglobin protein*-This discovery was found by using an electrical field to separate the proteins and peptidesThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-The normal cell peptide contains the amino side chain (Glu) at the 6th position-The sickle cell peptide contains the amino side chain (Val) at the 6th position-This small change in one amino group cause the whole cell to function and react diferently-Sickle disease is hereditary because DNA codes for the
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