BIOSC 150 1nd Edition Lecture 27Outline of Last Lecture I. Study of DiseaseII. Breast CancerOutline of Current Lecture 1. Study of EnzymesCurrent Lecture- Macromolecules (from food) undergo a catabolic reaction to provide energy in humans- The process is as follows: Food-> Amino Acids->ATP->Anabolic Reaction (active transport movement)- Enzymes are typically proteinsEnzymes- catalyst that speeds up biochemical reactions (although reactions would still occurin absence of an enzyme)Why are chemical reactions slow?1. Reactants must collide in a precise orientation to facilitate making new bonds2. Reactants must have enough energy (kinetic energy) to overcome repulsion with bonds- Non-biological way to help reactants reach transition state is with the addition of heat- Biological way to help reactants reach transition state is with the addition of enzymes- Enzymes stabilize the transition state and lower the activation energy but have no effect on free energyEnzyme Process:These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.1. Initiation: Enzyme orients substrate to allow the reaction process to be fulfilled2. Transition State Stabilization: Enzymes lower the activation energy (which is the least stable state)3. Termination: After catalysis, products are released and the enzyme remains unchanged from the reactionActive Site- imparts substrate specify (folded conformation generates binding pocket lined by specific amino acids)- Substrates are held in the active site with transient bonds between the enzyme and the
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