BIOSC 150 1nd Edition Lecture 18Outline of Last Lecture I. Biology of InheritanceOutline of Current Lecture 1. Genetics2. Offspring3. InheritanceCurrent Lecture-Inheritance particles (gene alleles) do not blend and remain inseparable in later generationsPrinciple of segregation- inheritance particles segregate into different gamete cells-Mendel’s phenotypes showed clear dominance, not blended-Some phenotypes show intermediate character (incomplete dominance)-F2 shows inherited traits remain inseparable-At the cellular level, phenotype may be co-dominant-DNA is the inherited material-Chromosomes contain the inheritance particle genes-As humans, we inherit 2 copies of each chromosome-Gametes contain one copy of each chromosome type as homologous chromosomes segregate-Non-homologous chromosomes assort independently into gametesCase Study: Cystic Fibrosis-Inheritance of the disease is recessive**Compare toCase Study: AchondroplasiaThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-Inheritance of the disease is of dominant pattern-Caused by single change in amino acid sequence (380 position)-Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism – achnodroplasia-FGFR3 signaling inhibits bone
View Full Document
Unlocking...