BIOSC 150 1nd Edition Lecture 24Outline of Last Lecture I. Genetics of CardiomyopathyII. Crossing overOutline of Current Lecture 1. Genetics Vs. GenomicsCurrent Lecture- A genome is composed of 3 billion nucleotides times 2- Most DNA is not protein coded- Fewer genes on the Y chromosome as compared to the X chromosome - Y chromosome responsible for maleness- Average chromosome has 1,000 genes- The X chromosome doesn’t relate to sex or gender- X chromosome does relate to sex linked disease-These phenotypes are only displayed in males (How you know the disease is coming from the X chromosome- One out of every 1000 nucleotides are different - Most DNA is not genesGenetics- sequence specific genes for mutation known to cause specific disease, can be associated with the risk of diseaseGenomic- looks through your whole genome and tries to figure out everything it can tell us (sequencing everything)- Most differences among humans are single nucleotide polymorphisms (SNP); for instance it would be a deletion or replication of the nucleotide- Four ‘flavors’ possible at any given positionThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- SNP studies research a particular phenotype then look for SNP’s over the genome- Crossing over is rare between genes that are close, it usually occurs between genes that are far apart, take place during Meiosis
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