BIOSC 150 1nd Edition Lecture 12Outline of Last Lecture I. Subcellular StructuresOutline of Current Lecture 1. Subcellular structures continued2. Lysosomes 3. Exploring the Smooth ERCurrent Lecture-Macromolecules can enter the cell via receptor-mediated endocytosis-The low pH of early endosomes causes receptors to release their cargo-The late endosome receives acid hydrolases from the Golgi, which digests macromoleculesLysosomes- cell’s recycling center of acid hydrolases-All lysosomal hydrolases are tagged with mannose-6-phosphate in the Golgi-Lysosomes recycle damaged organelles and degrade engulfed partcilesAutophagy- recycling damaged organelles by fusing with the organellePhagocytosis- degrading of engulfed large particles-When lysosomal function is impaired, lysosomal storage disease occurs (Structure=Function)-pH alterations can cause malfunctions-Mannose-6-phophate alterations can cause malfunctionsSmooth ER VS Rough ER:-The SER does not contain ribosomes-The SER is the primary site of phospholipid synthesis-The SER is the site of cholesterol and steroid synthesisThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.-The SER is an important site for calcium storage-The SER is critical for detoxifying chemicals-Peroxisomes bud from the ER, contain oxidative enzymes, and metabolize fatty acids-Mitochondria: 1. Contain 2 membranes, 2. The cell’s power plant, 3. Contain DNA-Chloroplasts are surrounded by a double
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