Psyc4130 1nd Edition Lecture 29 Outline of Last Lecture I Neurodegenerative Disorders II Alzheimer s III Presentation and Progression IV Brain and Pathology in AD V Plaques and Tangles VI Beta Amyloid Plaques VII Neurofibrillary Tangles VIII Presenilin IX Apolipoprotein E ApoE X A Induced Toxicity XI Standard Rx Outline of Current Lecture I Video a Morris Water Maze b HDAK c Environmental Enrichment II Potential Therapies III Parkinson s IV Therapies for Parkinson s Current Lecture Video Morris Water Maze o Rats in murkey water try to swim to platform o Test for declarative memories in rats and mice HDAK Inhibitors epigenetic Environmental Enrichment o Rats with lots of toys and companions they swim straight to the platform and much faster o Somehow the mice got their memories back after it being destroyed o In video bring back part of function memory maybe memories can be restored o Loss of memories These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Potential Therapies Recent research with AD mice has revealed that it may be possible to sensitize the immune system against A In mice a vaccine against A halted and reversed the development of plaques In a 2003 study with 30 humans with AD the successfully produced antibodies and slowed the cognitive decline in of the patients Parkinsons Age progression Pathologies that effect cells are more specific and focused o Nigra striatum system dopamine producing cells that are being lost in Parkinson s Everyone would develop parkinsons disease if they lived long enough 90 95 are PD cases are sporadic aka non genetic Toxins and pesticides First onset noticeable sign hand tremor not associated with nervousness Onset of dementia occurs much more slowly than it does in alzheimers Hints in brain rare genetic cases Typically earlier in onset and more rapid in progression provide clues into the cytopathological processes involved in PF Alpha synuclein is a normal protein found in axon terminal region of DA neurons It aids in neurotransmission In a rare gentic form of PD a chromosome 4 defect produces toxic gain of function Abnormal alpha synuclein protein becomes mis folded and forms aggregations Affects only nigrostriatal cells A chromosome 6 anomaly in a gene producing the protein parkin causes a toxic loss of function Therapies for Parkinsons Dopamine L DOPA goes to neurons of brain increases biosynthesis of dopamine Surgical interventions figure 15 17 schematic of basal ganglia Stimulating electrodes in brain regulating neural activity within a particular structure
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