Notes for 3 23 15 BSCI105 Lecture Cellular Respiration Chapter 8 I The Kreb s Citric Acid Cycle a Transport of pyruvate mitochondrial matrix b Conversion of pyruvate i Pyruvate must be actively transported from the cytosol into the i Pyruvate acetyl coenzyme A CoA ii 3 step process using a single multi enzyme complex pyruvate dehydrogenase complex iii Occurs in mitochondrial matrix iv Step 1 oxidation of pyruvate 2 C yields 1 CO2 v Step 2 oxidation of 2 C acetate yields 1 NADH vi Step 3 acetate CoA acetyl CoA unstable sulfide bond is highly reactive c Acetyl CoA i Produced by oxidation of pyruvate ii Product of metabolism of 1 Proteins 2 Fats 3 Other lipids iii Can be used 1 For fat synthesis 2 For ATP production into Acetyl CoA for use by the Kreb Cycle d Yield per turn on the Kreb s Cycle i 1 ATP substrate level phosphorylation ii 3 NADH iii 1 FADH2 iv CLICKER QUESTION when pyruvate enters the mitochondria it is converted iv 2 CO2 e 2 turns around cycle per glucose molecule f Oxaloacetate acetyl CoA citrate g Glycolysis and Kreb s Cycle Glucose 4 ADP 4 Pi 10 NAD 2 FAD 6 CO2 4 ATP 10 NADH 2 FADH2 II Oxidative Phosphorylation Electron Transport and Chemiosmosis a Uses membrane proteins in mitochondria b Uses oxyden c Uses the transfer of electrons from Kreb s cycle oxidation reduction reactions d Catabolism of Glucose i Movement of electrons 1 Some molecules are oxidized 2 Some molecules are reduced 3 delta G 52 4 kcal mol lot of energy compared to substrate level phosphorylation 4 NADH H O2 NAD H2O e Electron Transport Chain ETC i Series of protein complexes and organic molecules embedded in inner mitochondrial membrane ii Coordinated in a series of redox reactions iii Final electron acceptor is molecular oxygen O2 iv Electrons can enter the ETC from NADH or from FADH2 v Electrons leave the ETC using oxygen as the final electron acceptor vi CLICKER QUESTION if oxygen is the final electron acceptor for the ETC then oxygen must become reduced
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