Notes for 4 20 15 BSCI105 Lecture Regulation of Gene Expression Chapter 18 I Cells in YOUR body a All have same genomic DNA b Only express 20 of genes at the same time II Gene regulation in eukaryotes a Winds up tight to hide gene so that it is never used again b Altering DNA structure c Transcriptional control d Post transcriptional control e Translational control f Post translational control g CLICKER QUESTION at what level are most eukaryotic genes regulated in different types of cells Transcription III Transcriptional control a Most eukaryotic gene expression is controlled at this level b Genes must be available for transcription chromatin remodeling c Some genes are transcribed all the time constitutive d Other genes require transcription factors regulated e Chromatin regulation i Nucleosome 1 DNA on histone complexes 2 Histones a Acetylation gene available b Methylation heterochromatin
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