BIOSC 150 1nd Edition Lecture 25 Outline of Last Lecture I Genetics Vs Genomics Outline of Current Lecture 1 Study of Disease 2 Breast Cancer Current Lecture The general population lifetime risk for a woman to develop breast cancer is 12 12 from genes and environment genetic heritability contribution 30 of 12 and environment contribution 70 of 12 But in some families the lifetime risk is MUCH higher 60 90 lifetime risk of developing breast cancer Mary Claire King used linkage mapping to find breast cancer risk to on a chromosome region Certain allele flavors of all these genes increase cancer risk But most breast cancer patients do not inherit mutations in these genes o ATM BARD1 BRCA1 BRCA2 BRIP1 CDH1 CHEK2 MLH1 MRE11A MSH2 MSH6 MUTYH NBN PALB2 PMS1 PMS2 PTEN RAD50 RAD51C STK11 and TP53 Mutations in BRCA1 and 2 Breast Cancer genes 1 and 2 are associated with high increased risk of developing breast cancer o Not everyone with the BRCA 1 allele develops breast cancer Chromosomes replicate before mitosis and condense in mitosis Homologous chromosomes do not pair in mitosis Sister chromatids separate in mitosis Malignant tumor cells divide without cell cycle control AND move to new places in the body These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Cancer cells have accumulated multiple mutations o People with BRCA mutation inherit a first mutation in every cell Of the roughly 75 million adult women in the U S about 250 000 carry a mutation in BRCA1 That represents 33 of those who have been tested Not to be cavalier or decrease the significance of this situation just to put it into a more honest perspective Dr Erika s Blog
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