BIO 446L 1st Edition Lecture 8 Outline of Last Lecture I. Bone Continueda. Bone cellsi. Osteocytesii. Osteoclastsb. Bone formationi. Woven boneii. Lamellar bonec. Bone repair and remodelingd. Osteogenesisi. Intramembranous ossificationii. Endochondral ossificatione. Interstitial bone growthf. Regulation of bone metabolismOutline of Current Lecture I. Review day for testCurrent LectureAdditional Points and Clarifications on Bullet Points from Dr. Hines’s Study Guide- H & Eo Structure stained is acidophilic of basophilic (red or blue)o More important to know what you’re looking at, not the histology methods- PASo Stains sugars darkly- Epitheliao Dr. Hines suggests to make a chart of structures, types, and associated MA’so Glandular epithelia—holocrine (whole cell), merocrine (most common), and apodcrine (apical end buds off, exocytosed)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o Know proteins that make up each type of epithelial cell junctions- Connective Tissueo Phenotypic changes Fibroblasts fibrocytes- Blasts: larger nucleus, basophilic cytoplasm- Cytes: spindle shaped nucleus, acidophilic nucleus Macrophages (active and inactive)- Active: at site of infectiono phagocytic (long processes to increase surface area)o antigen presentingo lots of lysosomes (in a micrograph looks like dark bubbles because they are electron dense) chondroblasts and osteoblasts go to chondrocytes and osteocytes- BUT these cytes do NOT revert back to blasts once trapped in lacunae- Boneo Calcium mobilization Calcitonin and PTHo Know how to make a list of steps in intramembranous ossification- Be able to draw the basement membrane and components- Cancero Look at the intermediate filaments to determine the primary source of metastasized tissue Intermediate filaments are very tissue specific (see chart in
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