BIO 446L 1st Edition Lecture 5 Outline of Last Lecture I. Epithelial tissue contda. Types of epitheliai. Squamous, cuboidal, columnarii. Simple and stratifiediii. GlandularII. Connective Tissuea. Fibrocytes and fibroblastsb. Macrophagesc. Mast cellsOutline of Current Lecture I. Connective Tissue Contda. Collagenb. Reticularc. Elasticd. Ground substancei. GAGsii. Proteoglycaniii. Multiadhesive glycoproteinsII. Adipose Tissuea. White adipose tissueCurrent LectureConnective Tissue Continued- Collageno types Type IV—basal lamina Type VII—anchoring Type III- reticular layer (below basal)o SynthesisThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute. Synthesized in stages- First stage is procollagen- Glycine at every third position- Alpha chain triple helix- Hydroxylation of chemicals in procollagen- Helices aggregate into tight patterns of distinct lengthso This is why you can observe striation patterns- Compose the ECFo Reticular fibers Compose the ECF Type III collagen Heavily glycosylated- What makes it argyrophillico Stains black- PAS positiveo Stains very brightly because contains lots of sugarso Elastic fibers Also a component of the ECM Fibrillin- Lays down scaffold Elastin- Lays down in clumps over fibrillin scaffold, forming the elastic tissue MA—Marfan Syndrome- Susceptible to aortic rupture (aneurism)o Ground Substance Heavily hydrated molecules- Makes it very viscous Composed of Glycosaminoglycans (GAGs), Proteoglycans, Multiadhesive glycoproteins GAGs- Hyaluronic acido Big chain, secreted by cell wall, makes very viscous- Glycosamine glycan found mostly in jointso Lubricates Proteoglycans- Core protein + GAG- Also heavily hydrated (lubricates)- Syndecan—spans cell membrane- Many proteoglycans also store growth factorso FGF= fibroblast growth factor Multiadhesive glycoprotein- Lots of binding sites- Help link ECM structures to cell surface- Fibronectino Found outside cells, binds collagens, GAGs, integrins- Laminin—basal lamina- Integrins—receptors that link to glycoproteins and stabilize themo Types of Connective Tissue Loose connective (areolar) Dense irregular connective- Collagen in several different planes Dense regular connective- Tendons and ligaments- Synovial capsule- Finely longitudinal layers of collagen Reticular- Lacy, PAS positive, argyrophillic networkAdipose Tissue- A connective tissueo Originates from mesenchymeo Surgeons avoid cutting fat because there are a lot of blood vesselso Major regulator of metabolism and energy storageo Leptin—secreted by adipocyteso Brown fat Small droplets of triglyceride storage dispersed throughout the cello White fat Droplets of triglyceride stored concentrated in one area- White adipose tissueo Concentrated fat droplet storageo Nucleus very peripheralo Lots of blood vesselso Stains black with osmium—stains phospholipids, so the membrane can be easily seeno Leptin= satiety hormone Tells you you’re fullo Subcutaneous fat Everywhere just below surface of skino Visceral fat Deeper storage What makes you
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