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Berkeley MCELLBI 140 - MCB 140 FINAL EXAM

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NAME: _____________________________________ STUDENT ID #: ______________________________ Page 1 of 17 MCB 140 FINAL EXAM Spring 2007 NAME (Please print):__________________________________________ STUDENT ID #:_______________________________________________ REMINDERS You have 180 minutes for the 225 point exam. Print your name and ID# on each page of the exam. You will lose points if you forget to do this. There are 17 pages total, including this cover page. The last two pages are work space (no problems). All pages must be turned in. Only the front of each page will be graded. If you use the back of a page, transcribe your answer to the front of the page. Use a non-programmable calculator. ----------------------------------------(Do not write below this line)--------------------------------------- 1 (25) _____ 2 (11) _____ 3 (2) _____ 4 (2) _____ 5 (7) _____ 6 (3) _____ 7 (35) _____ 8 (10) _____ 9 (15) _____ 10 (15) _____ 11 (10) _____ 12 (10) _____ 13 (15) _____ 14 (20) _____ 15 (10) _____ 16 (5) _____ 17 (10) _____ 18 (20) _____ TOTAL _____ / 225NAME: _____________________________________ STUDENT ID #: ______________________________ Page 2 of 17 Questions on Prof. Urnov’s section 1. The following is Fig. 5.13 from your textbook. It shows one of the most majestic achievements of the scientific method: a map of the Drosophila genome obtained without any knowledge of the chemical basis of heredity – i.e., solely via genetic analysis.NAME: _____________________________________ STUDENT ID #: ______________________________ Page 3 of 17 (a) (5 pts) We talked about the fact that unlinked genes recombine at a frequency of 50%. That said, for some reason, the genetic distance on Chr. 1 between two linked genes, aristaless antenna and blistered wings, is a whopping 107 map units. How could this impossible value have been experimentally measured? Did they observe recombination 107% of the time?! (b) (20 pts) A white-eyed, male with normal veins on its wings and a body of wild-type color is mated to a red-eyed female with thick-veined wings and a black body. All the progeny of this cross are wild-type. Female progeny of this cross are mated to white-eyed males with thick veins on their wings and a black body. One thousand progeny from this cross are phenotyped. Write out the phenotypic classes observed in this progeny and the number of flies in each class, assuming perfect compliance with the genetic distances shown above, and perfect compliance with Mendel’s laws.NAME: _____________________________________ STUDENT ID #: ______________________________ Page 4 of 17 Questions on Prof. Cline’s section For each question below (2-6), BRIEFLY EXPLAIN your answer, even if your answer is, “there is no logical basis from Genetic principles and/or vocabulary for an answer other than "can't say", based on the information provided.” Remember not to overthink the questions. 2. Consider two different dominant gain-of-function alleles of the same gene in the German Shepherd dog. QA is an antimorph, while QH is a hypermorph. The phenotype of the null Q allele is no tail, and the mutant allele is fully recessive. (a) (2 pts): What can you say about the likely phenotype of a QA/+ German Shepherd? (b) (2 pts): Would you expect the mutant phenotype of QA/+ dogs to be qualitatively similar to that of QH/+ dogs, or instead be qualitatively different? (c) (2 pts): QA/QH dogs are wildtype. Would it be correct therefore to say that the two gain-of-function alleles complement? (d) (3 pts): If we "reverted" the dominance of QA and QH, generating QA* and QH* respectively, what would the likely phenotype be of a QA*/QH* dog? (e) (2 pts.): In light of the information given you in part c above, what, if anything, could you predict about the phenotype of a QA,H/Q+ dog, if you were told that QA and QH satisfy expectations for a cis-trans test for allelism? Assume that QA,H is a doubly mutant allele created by recombination between QA and QH (not very likely, of course).NAME: _____________________________________ STUDENT ID #: ______________________________ Page 5 of 17 3. (2 pts.) The mutagen ethylmethane sulfonate will generate null alleles, but it is particularly effective at generating a wide spectrum of hypomorphic point mutants as well. Brenner and crowd used proflavin as the mutagen for the rII gene of phage T4 in their famous experiments exploring the nature of the genetic code. They demonstrated that the genetic code was commaless in part by showing that certain of their point mutant alleles could be suppressed by certain other of their point mutant alleles. Do you think that some of the mutations they induced in rII by proflavin would likely be suppressed by some of the mutations that one might typically induce in rII by ethylmethane sulfonate? 4. (2 pts) To move DNA around, fly workers generally use an engineered immobile genetic source of P-element transposase called "delta-2,3", derived from DNA that was originally introduced into an M-strain animal. After many generations, will female flies from the delta-2,3 strain eventually come to behave like P-strain females and generate eggs with a P cytotype? 5. The mechanism of sex determination can be remarkably messy in some species, with different races of the same species having different GSD systems operating. Consider such a species in which race Q has a ZZ-ZW system of the active W type, while race R of the same species (but geographically isolated from the other) has an XX-XY system of the active Y type. The Z and X chromosomes of the two races are essentially identical genetically, and this sex chromosome carries 10% of all the genes. In contrast, the W and Y chromosomes carry very few genes. (a) (2 pts) Which, if either, of the two races is/are likely to need a sex-chromosome dosage compensation system? (b) (2 pts) Which, if either, of these species is likely to use a sex-chromosome:autosome balance system of sex determination?NAME: _____________________________________ STUDENT ID #: ______________________________ Page 6 of 17 (c) (3 pts) If you crossed a Q strain male with an R strain female, what would you expect the sexual phenotype(s) of the offspring to be? 6. (3 pts) Given the following genotype of fruit fly: FRT a- b+ c- d- e+


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Berkeley MCELLBI 140 - MCB 140 FINAL EXAM

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