Berkeley MCELLBI 140 - CLINE 11 (19 pages)

Previewing pages 1, 2, 3, 4, 5, 6 of 19 page document View the full content.
View Full Document

CLINE 11



Previewing pages 1, 2, 3, 4, 5, 6 of actual document.

View the full content.
View Full Document
View Full Document

CLINE 11

90 views

Lecture Notes


Pages:
19
School:
University of California, Berkeley
Course:
Mcellbi 140 - General Genetics
General Genetics Documents

Unformatted text preview:

Reading pp152 154 Mitotic recombination can produce genetic mosaics and cause cancer I ve asked to reserve a lecture room from 7 9pm Thursday April 5 for a review session in connection with the midterm on Monday April 9 I ll announce where the session will be held as soon as I know myself Last Friday 1 genetically sensitize the system turn lof recessives into dominants but only with respect to one non essential aspect of their function Poising the activity level of your favorite gene on a phenotypic threshold to make other genes haploinsufficient but only with respect to the functioning of your favorite gene So that 1 we can identify new mutations of interest in the F1 generation first generation after mutagenizing the parents AND 2 can overcome some complications of pleiotropy so that we can more easily study the non vital aspects of the functioning of genes that ALSO have vital functions 1 genetically sensitize the system turn lof recessives into dominants but only with respect to one non essential aspect of their function Based on the rationale that Wildtype fly must normally have an excess of most genes activity as insurance against fluctuations in the levels of activity of various genes in a pathway during development if take away that cushion for any one gene in a pathway now make the normal operation of the pathway with respect to that one gene more vulnerable to reductions in other gene levels Another way around the limitations of pleiotropy in genetic screens 2 use targetted genetic mosaics to screen for recessives in the F1 homozygous clones in heterozygotes in non essential tissues only recover new recessives in the F1 without making them dominant genetic mosaics according to your text an organism containing tissues of different genotypes cells all derived from a single initial cell zygote genetic mosaic vs organism genetic chimera an embryo or animal composed of cells from two or more different organisms individuals and that s what they say in the text



View Full Document

Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view CLINE 11 and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view CLINE 11 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?