Berkeley MCELLBI 140 - Practice exam answers (8 pages)

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Practice exam answers



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Practice exam answers

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Pages:
8
School:
University of California, Berkeley
Course:
Mcellbi 140 - General Genetics
General Genetics Documents

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Name KEY SID MCB140 Practice Exam 1 Under harsh environmental conditions C elegans can enter an alternate third larval stage known as the dauer stage Animals can live in this stage for months until conditions improve allowing them exit the dauer stage and complete their life cycle Two types of mutants that are defective in dauer development exist Dauer constitutive mutants enter the dauer stage even when environmental conditions are good and dauer defective mutants are unable to enter the dauer stage The conserved insulin regulatory pathway is required for dauer development Loss of function mutations in genes of the insulin pathway cause either dauer constitutive or dauer defective phenotypes a PI3 kinase is a signaling molecule in the insulin pathway and one of the PI3 kinase subunits is encoded by the age 1 gene In a cross between a homozygous age 1 hermaphrodite and a wild type male individual hermaphrodite F1 cross progeny that are heterozygous for the loss of function age 1 mutation generate all normal not dauer F2 self progeny When individual F2 hermaphrodite self progeny are transferred to separate petri plates 3 4 have F3 self progeny that are normal and 1 4 of them have F3 self progeny that are all dauer The growth conditions used will not induce dauer formation in wild type animals Define the genotypes of the F2 progeny of the heterozygous hermaphrodite and whether they will have normal or dauer progeny Also explain why none of them are dauer 1 4 will be and will have normal progeny 1 2 will be age 1 1 and will have normal progeny 1 4 will be age 1 age 1 and will have all dauer progeny They are not dauer because age 1 is a maternal effect gene 1 Name KEY SID b The FOXO transcription factor is encoded by the daf 16 gene Signaling though the insulin receptor which is encoded by the daf 2 gene activates PI3 kinase which eventually leads to the phosphorylation and inhibition of DAF 16 FOXO From what you know about age 1 and the pathway just described what will



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