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WSU PSYCH 333 - Mood Disorders
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PSYCH 333 1nd Edition Lecture 6 Outline of Last Lecture II. Research BasicsIII. Case StudyIV. Correlation DesignV. Experimental DesignVI. Meta-Analysis Outline of Current Lecture II. Mood DisordersIII. Depressive DisordersIV. Bipolar DisordersV. Major Depressive DisorderVI. Persistent Depressive DisorderVII. Subtypes of Depressive DisordersVIII. Etiology of Depression – BiologyIX. Biological TreatmentCurrent Lecture- Mood Disorders:o What is mood? A feeling that happens and last over time.o When does mood become abnormal? When it starts interfering with one’s day-to-day life, it lasts for a really long time, and can be harmful to one’s self.- Depressive disorders:o Major depressive disorder.o Persistent depressive disorder.o Premenstrual depressive.o Disruptive mood deregulation.- Bipolar disorders:o Bipolar I disorder.o Bipolar II disorder.o Cyclothymic disorder.- Think-pair-share:o What is depression? Feeling sad for a long period of time, lack of interest in fun activities, negative thoughts, and lack of care for one’s health.These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- Major Depressive Disorder:o Emotional symptoms; depressed mood, lack of interest/loss of pleasure, feeling of guilt/worthlessness/hopelessness.o Cognitive symptoms; difficulty concentrating/making decision, suicidal ideation/thoughts of death.o Somatic/behavioral symptoms; sleep disruption, appetite, disruption, changes in motor activity, fatigue.o Symptoms last for at least two weeks.o Course of Major Depressive Disorder. Episodic. Most common age of onset is early 20s. Severity of symptoms typically diminishes with time.o Prevalence. The most common mental disorder – 16-20% of the population will meet this criteria for MDD at some point in their lives.o Associated features. High mortality rate – not just due to suicide. HPA-axis activation.- Persistent Depressive Disorder:o Same symptoms as MDD. Pure Dysthymic – fewer symptoms than MDD. Chronic MDD – same number of symptoms as MDD.o Symptoms persist for at least two years.o Main difference is the course of the disorder: chronic vs. episodic.o Typical age of onset in earlier – late childhood/early adolescence.o More likely to have sleep abnormalities than in MDD.- Subtypes of Depressive Disorder:o Atypical features; mood reactivity, increased appetite, hypersomnia, leaden paralysis.o Melancholic features; loss of pleasure, profound despondency, early morning awakening, loss of appetite, psychomotor agitation, guilt, symptoms are worse inthe morning.o Anxious distress; anxious symptoms; restlessness, worry, fear, tense.o Psychotic features; hallucinations and/or delusions; congruency with mood.o Seasonal pattern.o Peripartum onset, depression right around the end of pregnancy or shortly after birth.- Etiology of Depression – Biology:o Genetics: MDD is 35-40% heritable.o Macro-anatomy. Dorsolateral PFC – emotion regulation, concentration, rumination (thinking about a negative thought over and over again). Amygdala – overactive; rumination, fear. Hippocampus – context-dependent learning inhibited. ACC – emotional pain/distress.o Microanatomy. Serotonin. Dopamine. Norepinephrine.o Neuroendocrine system. HPA-axis activation. Role of cortisol in somatic symptoms. Impact of cortisol on hippocampus.- Biological Treatments:o Antidepressants. Monoamine oxidase inhibitors (MAO-I). Tricyclic antidepressants. Serotonin reuptake inhibitors (SSRIS). Serotonin norepinephrine reuptake inhibitors (SNRIS). Bupropion (dopamine norepinephrine reuptake inhibitors).o Electroconvulsive therapy (ECT).o Light therapy (for MDD with seasonal


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WSU PSYCH 333 - Mood Disorders

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