BIOL 1107 1nd Edition Lecture 11 Outline of Last Lecture I. Sodium-potassium pumpII. Proton pumpIII. Co-transportIV. Influenza cell entryOutline of Current Lecture I. CFTR Protein & Cystic FibrosisII. NucleusIII. Endoplasmic ReticulumIV. CytoskeletonCurrent LectureI. CFTR Protein & Cystic FibrosisThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- What is cystic fibrosis? Disease that has very poor life expectancy; thickened mucosa in the lungs due to chloride transport malfunction. Chloride gets stuck insideepithelial cell- **Mrs. Constable stated that she will not ask specific questions about cystic fibrosisII. Nucleus- Largest structure in cell- DNA -> in chromosomes - Nuclear pore- transport in and out of cell- Nucleoli- produces ribosomes - Ribosomes go out through nuclear pore - Nuclear envelope- contain phospholipids; what’s unique about this membrane? It’s adouble membrane- Why DNA shouldn’t leave nucleus? Contains genes and is protecting those genes- RNA -> (leaves nucleus) so that we can protect DNA and amplify amount of protein that gets madeIII. Endoplasmic Reticulum- Rough ER -> proteins- Smooth ER -> detoxifying, production of lipids, calcium ion storage, carbohydrate metabolism- Usually wrapped around nucleus- What proteins are made in ER? Secreted proteins and membrane proteins- How ribosome knows whether to go to ER or cytoplasm? Signal peptides- How do we move protein to Golgi? Via vesicles- Transport vesicles -> move proteins through cytoskeleton (microtubules, etc)IV. Cytoskeleton- reinforces cell’s shape, functions in cell movement; components are made of protein.- Three major types:1. Microtubules: function- movement/shape; cilia/flagella/centrioles2. Microfilaments: actin (contraction, important in muscles); shape/tension3. Intermediate filaments: laminin (holds organs in place-
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