BIOL 1107 1nd Edition Lecture 10 Outline of Last Lecture I. Proteins & NutritionII. MembranesIII. Properties of Membrane ProteinsOutline of Current Lecture I. Sodium-potassium pumpII. Proton pumpIII. Co-transportIV. Influenza cell entryCurrent LectureI. Sodium-potassium pumpThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- This transport system pumps ions against steep concentration gradients- Sodium ion concentration: high outside cell and low inside- Potassium ion concentration: low outside cell and high inside- Pump oscillates b/n two shapes in a pumping cycle that translocates 3 sodium ions out of cell for every two potassium ions pumped into cell- The two shapes have different affinities for two types of ions- ATP powers shape change by phosphorylating transport protein (that is, by transferring a phosphate group to protein)II. Proton pump- Proton pump- actively transports hydrogen ions (protons) out of cell- Main electrogenic pump of plants, fungi and bacteria- Pumping of H+ transfers positive charge from cytoplasm to extracellular solution- In what type of specialized cells would this pump be important? Stomach cells- Stomach acid -> H+ pump, Prilosec and Nexium (proton pump inhibitors & histamine blockers)- See Figure on next pageIII. Co-transport- Glucose is higher inside cells- This process doesn’t use ATP- Transports both glucose and sodium ions at the same time (symport)- Sodium-chemical gradient, electrical gradientIV. Endocytosis, Exocytosis, Phago/Pinocytosis- How do big molecules cross? Via endocytosis, exocytosis, phagocytosis (for big bacterium), pinocytosis (cells drinks environment)V. Influenza Cell Entry- Proton pump (H+) decrease pH in cell, causes change in structureQ: Cells in CF patient’s transport chloride (Cl-) out of cell poorly. As a result, external spaces in lung tissue are Cl- deficient. Which of the following could result? A: Too little water would move from cells into
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