BIOL 1107 1nd Edition Lecture 10 Outline of Last Lecture I Proteins Nutrition II Membranes III Properties of Membrane Proteins Outline of Current Lecture I Sodium potassium pump II Proton pump III Co transport IV Influenza cell entry Current Lecture I Sodium potassium pump These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute II This transport system pumps ions against steep concentration gradients Sodium ion concentration high outside cell and low inside Potassium ion concentration low outside cell and high inside Pump oscillates b n two shapes in a pumping cycle that translocates 3 sodium ions out of cell for every two potassium ions pumped into cell The two shapes have different affinities for two types of ions ATP powers shape change by phosphorylating transport protein that is by transferring a phosphate group to protein Proton pump Proton pump actively transports hydrogen ions protons out of cell Main electrogenic pump of plants fungi and bacteria Pumping of H transfers positive charge from cytoplasm to extracellular solution In what type of specialized cells would this pump be important Stomach cells Stomach acid H pump Prilosec and Nexium proton pump inhibitors histamine blockers See Figure on next page III Co transport IV Glucose is higher inside cells This process doesn t use ATP Transports both glucose and sodium ions at the same time symport Sodium chemical gradient electrical gradient Endocytosis Exocytosis Phago Pinocytosis V How do big molecules cross Via endocytosis exocytosis phagocytosis for big bacterium pinocytosis cells drinks environment Influenza Cell Entry Proton pump H decrease pH in cell causes change in structure Q Cells in CF patient s transport chloride Cl out of cell poorly As a result external spaces in lung tissue are Cl deficient Which of the following could result A Too little water would move from cells into mucous
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