BIOSC 150 1st Edition Lecture 30 Outline of Last Lecture I Study of Energy Outline of Current Lecture 1 Harvesting Energy 2 Pyruvate Processing Current Lecture Aerobic Respiration getting more out of Glucose Pyruvate processing allows cellular respiration to proceed Pyruvate needs to cross two mitochondrial membranes o Outer membrane porins large non selective channels o Inner membrane mitochondrial pyruvate carrier Pyruvate processing decarboxylation generation of NADH AcCoA o Oxidation reaction NAD is reduced Pyruvate Acetyl CoA Pyruvate dehydrogenase complex performs a series a complex reactions o E1 30 subunits o E2 60 subunits o E3 12 subunits PDH complex is too big to crystallize we get an idea of what the structure looks like through cyro electron microscopy E1 the rate limiting enzyme of PDH complex is regulated by phosphorylation o Phosphate groups are added to the enzyme through the use of Kinase o Phosphorylation of E1 renders it inactive therefore turning if off These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute o Kinase and phosphatase are opposite pairs therefore the use of phosphatase will turn the enzyme back on Acetyl CoA feeds into the citric acid cycle Citric Acid Cycle regenerates product to cycle generates energy with NADH FAD ATP and decarboxylation of Co2 Loss of CoA Fuel for the endergonic reactions in the cycle Citric cycle runs twice for each glucose produced Feedback inhibition regulated by NADH and ATP o NADH competitive inhibition o ATP allosteric inhibition Glycolysis and Pyruvate processing fully metabolizes and oxidizes glucose
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