BIOSC 150 1nd Edition Lecture 27 Outline of Last Lecture I Study of Disease II Breast Cancer Outline of Current Lecture 1 Study of Enzymes Current Lecture Macromolecules from food undergo a catabolic reaction to provide energy in humans The process is as follows Food Amino Acids ATP Anabolic Reaction active transport movement Enzymes are typically proteins Enzymes catalyst that speeds up biochemical reactions although reactions would still occur in absence of an enzyme Why are chemical reactions slow 1 2 Reactants must collide in a precise orientation to facilitate making new bonds Reactants must have enough energy kinetic energy to overcome repulsion with bonds Non biological way to help reactants reach transition state is with the addition of heat Biological way to help reactants reach transition state is with the addition of enzymes Enzymes stabilize the transition state and lower the activation energy but have no effect on free energy Enzyme Process These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 1 Initiation Enzyme orients substrate to allow the reaction process to be fulfilled 2 Transition State Stabilization Enzymes lower the activation energy which is the least stable state 3 Termination After catalysis products are released and the enzyme remains unchanged from the reaction Active Site imparts substrate specify folded conformation generates binding pocket lined by specific amino acids Substrates are held in the active site with transient bonds between the enzyme and the substrate
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