BIOSC 150 1nd Edition Lecture 18 Outline of Last Lecture I Biology of Inheritance Outline of Current Lecture 1 Genetics 2 Offspring 3 Inheritance Current Lecture Inheritance particles gene alleles do not blend and remain inseparable in later generations Principle of segregation inheritance particles segregate into different gamete cells Mendel s phenotypes showed clear dominance not blended Some phenotypes show intermediate character incomplete dominance F2 shows inherited traits remain inseparable At the cellular level phenotype may be co dominant DNA is the inherited material Chromosomes contain the inheritance particle genes As humans we inherit 2 copies of each chromosome Gametes contain one copy of each chromosome type as homologous chromosomes segregate Non homologous chromosomes assort independently into gametes Case Study Cystic Fibrosis Inheritance of the disease is recessive Compare to Case Study Achondroplasia These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Inheritance of the disease is of dominant pattern Caused by single change in amino acid sequence 380 position Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism achnodroplasia FGFR3 signaling inhibits bone growth
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