BIOSC 150 1nd Edition Lecture 17 Outline of Last Lecture I Data Analysis II Experimental Design III Progeria Outline of Current Lecture 1 Biology of Inheritance Current Lecture DNA is the biomolecule of inheritance DNA strands are both copied in DNA replication DNA can be copied using old strands as templates and this is important for cells receiving inheritance traits Chromosomes DNA wrapped around proteins DNA is therefore wrapped into chromosomes Sperm and Egg each have a haploid set of DNA chromosomes Diploid haploid from mother haploid from father The new diploid embryo will therefore have 2 sets of chromosomes DNA changes are mutations changes in DNA can occur during replication Why do we research inheritance 1 Diseases are inherited therefore to stop inherited diseases from being carried to their offspring 2 Study what traits are best for environments and what is an adapted trait 3 To find patterns in inheritance 4 To control breeding pertaining to animals Limitations Hard to find cures for diseases because most diseases are controlled by multiple genes These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Mendel s Research Studied patterns in inheritance but not DNA Looked at phenotypes in pea plants Controlled cross breeding between 2 different pure breeds Looked at patterns over multiple generations Research Question Do phenotypes blend in offspring Experiment Cross pollinated round peas with wrinkled peas Research Results All peas were round therefore phenotypes in the F1 generation do not blend instead there are recessive and dominant genes Mendel saw patterns in the inheritance Punnett Squares predict offspring phenotype genotype and ratios Pompe Disease Unable to break down sugars glucose Death threatening most patients die around 2 years old Effects muscles Phenotype of Pompe Patients 1 Weak 2 Misshaped faces 3 Weak skeletal muscles Patients are the product of recessive genes From Research Lysosomes are filled with glycogen cellular phenotype acid hydrolases in lysosomes not functioning Liposomal storage disease Glycogen Storage disease
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