BIOSC 150 1nd Edition Lecture 12 Outline of Last Lecture I Subcellular Structures Outline of Current Lecture 1 Subcellular structures continued 2 Lysosomes 3 Exploring the Smooth ER Current Lecture Macromolecules can enter the cell via receptor mediated endocytosis The low pH of early endosomes causes receptors to release their cargo The late endosome receives acid hydrolases from the Golgi which digests macromolecules Lysosomes cell s recycling center of acid hydrolases All lysosomal hydrolases are tagged with mannose 6 phosphate in the Golgi Lysosomes recycle damaged organelles and degrade engulfed partciles Autophagy recycling damaged organelles by fusing with the organelle Phagocytosis degrading of engulfed large particles When lysosomal function is impaired lysosomal storage disease occurs Structure Function pH alterations can cause malfunctions Mannose 6 phophate alterations can cause malfunctions Smooth ER VS Rough ER The SER does not contain ribosomes The SER is the primary site of phospholipid synthesis The SER is the site of cholesterol and steroid synthesis These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute The SER is an important site for calcium storage The SER is critical for detoxifying chemicals Peroxisomes bud from the ER contain oxidative enzymes and metabolize fatty acids Mitochondria 1 Contain 2 membranes 2 The cell s power plant 3 Contain DNA Chloroplasts are surrounded by a double membrane
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