BIOSC 150 1nd Edition Lecture 11 Outline of Last Lecture I Subcellular Structures Outline of Current Lecture 1 Subcellular structures continued A Protein Synthesis 2 Disease Current Lecture Steps in Protein Synthesis 1 2 3 4 Transcribe information encoded by DNA into mRNA Translate information encoded by mRNA into proteins Fold and modify proteins Deliver proteins to their proper place within or outside the cell The Nucleus Largest organelle Functions DNA replication transcription mRNA processing ribosome assembly Nuclear envelope double membrane selectively permeable barrier Nuclear Envelopes Roles 1 2 3 4 Regulates traffic to protect and separate Imports nucleotides for DNA and proteins Exports mRNA and ribosomes All traffic in and out of nucleus goes through the nuclear pores Nuclear pores connection between the nucleus and nuclear envelope Ribosomes assembled in the nucleus machines for protein synthesis All RER signal sequence steer ribosome translating endomembrane system and secreted proteins to the RER These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Proteins are folded and glycosylated in the RER lumen Chaperone proteins monitor folding Glycosolation is adding sugars to proteins Protein quality control occurs in the RER Proteasome degrades misused prtoteins The Golgi receives membrane bound packages of proteins vesicles for the RER Function of Glycosolation 1 2 3 4 Protect the proteins for degradation Interactions with other membranes Regulate protein function Target proteins
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